Associate Professor Gila Moalem-Taylor

• Fiore NT, Hayes JP, Williams SI, Moalem-Taylor G. Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice. Brain Behav Immun. 2024 Nov;122:287–300. doi:10.1016/j.bbi.2024.07.043.
• Wang W, Hassan MM, Kapoor-Kaushik N, Livni L, Musrie B, Tang J, Mahmud Z, Lai S, Wich PR, Ananthanarayanan V, Moalem-Taylor G, Mao G. Neural tracing protein-functionalized nanoparticles capable of fast retrograde axonal transport in live neurons. Small. 2024 Sep;20(39):e2311921. doi:10.1002/smll.202311921.
• Su TF, Hamilton JD, Guo Y, Potas JR, Shivdasani MN, Moalem-Taylor G, Fridman GY, Aplin FP. Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain. J Neural Eng. 2024 Apr 17;21(2). doi:10.1088/1741-2552/ad3b6c.
• Fiore NT, Keating BA, Chen Y, Williams SI, Moalem-Taylor G. Differential effects of regulatory T cells in the meninges and spinal cord of male and female mice with neuropathic pain. Cells. 2023 Sep 20;12(18):2317. doi:10.3390/cells12182317.
• Fiore NT, Debs SR, Hayes JP, Duffy SS, Moalem-Taylor G. Pain-resolving immune mechanisms in neuropathic pain. Nat Rev Neurol. 2023 Apr;19(4):199–220. doi:10.1038/s41582-023-00777-3.

Doctor Lipin Loo

• Loo L, Simon JM, Lei X, McCoy EM, Niehaus JK, Guo J, Anton ES, Zylka MJ (2019). Single cell transcriptomic analysis of mouse neocortical development. Nature Communications. Vol 10(1):134.
• Ocasio J, Babcock B, Malawsky D, Weir SJ, Loo L., Simon JM, Zylka MJ, Hwang D, Dismuke T, Sokolsky M, Rosen EP, Vibhakar R, Zhang J, Saulnier O, Vladoiu M, El-Hamamy I, Stein LD, Taylor MD, Smith KS, Northcott PA, Colaneri A, Wilhelmsen K, Gershon TR (2019). scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy. Nat Communications. Vol 20;10(1):5829.
• Niehaus JK., Taylor-Blake B, Loo L, Simon JM, Zylka MJ (2021). Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury. Neuron. Vol 109(8):1274-1282.
• Mickle AD, Shepherd AJ, Loo L, Mohapatra DP (2015). Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain. Vol 156(9):1620-36.
• Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, Jochum AK., Ali OH, Denes CE, Hamoudi Z, Chung F, Aggarwal A, Low JKK, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay JP, Jochum W, Flatz L, Hesselson D, Turville S, Neely G (2023). Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. PLoS Biology. Vol 21(2):e3001967.
• Manion J, Khuong T, Harney D, Littleboy JB, Ruan T, Loo L, Costigan M, Larance M, Caron L, Neely G (2020). Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain. Pain. Vol161(2):379-387.
• Ting KK, Coleman P, Kim HJ, Zhao Y, Mulangala J, Cheng NC, Li W, Gunatilake D, Johnstone DM, Loo L, Neely G, Yang P, Götz J, Vadas MA, Gamble JR (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. Geroscience. Vol 45(6):3307-3331.
• Khuong TM, Hamoudi Z, Manion J, Loo L, Muralidharan A, Neely GG. Peripheral straightjacket (α2δ Ca(2+) channel subunit) expression is required for neuropathic sensitization in Drosophila (2019). Philos Trans R Soc Lond B Biol Sci. Vol 11;374(1785):20190287.
• Loo L, Wright BD, Zylka MJ (2015). Lipid kinases as therapeutic targets for chronic pain. Pain. Vol 156(1):2-10.
• Xing L, Simon JM, Ptacek TS, Yi J, Loo L, Mao H, Wolter JM, McCoy ES, Paranjape SR, Taylor-Blake B, Zylka MJ. (2023). Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Cell Reports. Vol 42(7):112706.

Associate Professor Susan Hua

• Hua S*, Wu S. Advances & Challenges in Nanomedicine (eBook). Frontiers in Pharmacology, Switzerland, 153 (2019). DOI: 10.3389/978-2-88945-745-8
• Hua S*, Cabot PJ. PAIN – Novel Targets and New Technologies (eBook). Frontiers in Pharmacology, Switzerland, 95 (2015). DOI: 10.3389/978-2-88919-394-3
• Hua S*, de Matos MBC, Metselaar JM, Storm G. Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization. Front Pharmacol. 2018;9:790. DOI: 10.3389/fphar.2018.00790
• Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S*. Advances and Challenges of Liposome Assisted Drug Delivery. Front Pharmacol. 2015;6:286. DOI: 10.3389/fphar.2015.00286
• Hua S*. Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract – Influence of Physiological, Pathophysiological and Pharmaceutical Factors. Front Pharmacol. 2018;11:524. DOI: 10.3389/fphar.2020.00524
• Hua S*, Cabot PJ. Targeted Nanoparticles that Mimic Immune Cells in Pain Control Inducing Analgesic and Anti-inflammatory Actions: A Potential Novel Treatment of Acute and Chronic Pain Conditions. Pain Physician. 2013;16:E199-E216.
• Iwaszkiewicz K, Hua S*. Development of an effective topical liposomal formulation for localized analgesia and anti-inflammatory actions in the Complete Freund’s Adjuvant rodent model of acute inflammatory pain. Pain Physician. 2014;17:E719-E735.
• Hua S*, Dias TH, Pepperall DG, Yang Y. Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis. Front Pharmacol. 2017;8:503. DOI: 10.3389/fphar.2017.00503
• Hua S*, Vaughan B. In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications. Int J Nanomedicine. 2019;14:2191-2206. DOI: 10.2147/IJN.S198116
• Paul JW*, Hua S*, Ilicic M, Tolosa JM, Butler T, Robertson S, Smith R. Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor. Am J Obstet Gynecol. 2017;216:283.e1-283.e14. DOI: 10.1016/j.ajog.2016.08.027

Doctor Felicity Han

• Vygonskaya M, Wu Y, Price TJ, Chen Z, Smith MT, Klyne DM, Han FY* (2024). The role and treatment potential of the complement pathway in chronic pain. J Pain. Vol 27:104689. DOI: 10.1016/j.jpain.2024.104689
• Pang H, Chen S, Klyne DM, Harrich D, Ding W, Yang S, Han FY*. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research. Vol 11(1):42. DOI: 10.1038/s41413-023-00280-x
• Xu W, Kumar V, Cui CS, Li XX, Whittaker AK, Xu ZP, Smith MT, Woodruff TM, Han FY*. Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics. Vol 5(12):2200109. DOI: https://doi.org/10.1002/adtp.202200109  
• Han FY, Brockman DA, Nicholson JR, Corradini L, Smith MT (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology. Vol 33(1):23-31. DOI: 10.1097/fbp.0000000000000663
• Xu W, Maqbool F, Kumar V, Falconer JR, Cui CS, Woodruff TM, Borges K, Whittaker AK, Smith MT, Han FY*. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research. Vol 12(10):2518-2526. DOI: 10.1007/s13346-021-01093-3
• Zhu M, Whittaker AK, Jiang X, Tang R, Li X, Xu W, Fu C, Smith MT, Han FY* (2020). Use of Microfluidics to Fabricate Bioerodable Lipid Hybrid Nanoparticles Containing Hydromorphone or Ketamine for the Relief of Intractable Pain. Pharmaceutical Research. Vol 37(10):211. DOI: 10.1007/s11095-020-02939-0
• Han FY*, Liu Y, Kumar V, Xu W, Yang G, Zhao C, Woodruff TM, Whittaker AK, Smith MT (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics. Vol 581:119291. DOI: 10.1016/j.ijpharm.2020.119291
• Han FY, Whittaker A, Howdle S, Naylor A, Shabir-Ahmed A, Smith M (2019). Sustained-Release Hydromorphone Microparticles Produced using Supercritical CO₂ Micronization Technology. J Pharm Sci. Vol 108(2):811-814. doi: 10.1016/j.xphs.2018.09.021
• Han FY, Whittaker A, Howdle S, Naylor A, Shabir-Ahmed A, Zhang C, Smith M (2018). Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation. Pharmaceutics. Vol 10(4):264. DOI: 10.3390/pharmaceutics10040264
• Han FY, Thurecht KJ, Lam L, Whittaker AK, Smith MT (2015). Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. J Pharm Sci. Vol 104:2334–2344. DOI: 10.1002/jps.24497

Doctor Luke Grundy

• Grundy L, Caldwell A, Garcia Caraballo A, Erickson A, Schober G, Castro J et al. 2020, ‘Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H1receptor and TRPV1’, American Journal of Physiology-Renal Physiology, vol. 318, no. 2, pp. F298–F314
• Grundy L, Harrington AM, Castro J, Garcia-Caraballo S, Deiteren A & Maddern J et al. 2018, ‘Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction’, JCI Insight, vol. 3, no. 19
• Sharma H, Manning SK, Stevens NE, Bourlotos G, Ryan FJ, Tay C, et al. Acute urinary tract infection elicits bladder afferent hypersensitivity. Brain Behav Immun Health. 2025, vol 44, pages 100944
• Grundy L, Erickson A & Brierley SM. 2019, ‘Visceral Pain’, Annual Review of Physiology, vol. 81, pp. 261-284
• Brierley SM, Goh KGK, Sullivan MJ, Moore KH, Ulett GC, Grundy L. 2019, ‘Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors’, Pain, vol. 161, no. 1, pp. 202–210
• Grundy L, Harrington AM, Caldwell A, Castro J, Staikopoulos V, Zagorodnyuk VP et al. 2018, ‘Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice’, Pain, vol. 160, no. 4, pp. 793–804
• Grundy L, Erickson A, Caldwell A, Garcia-Caraballo S, Rychkov G, Harrington A et al. 2018, ‘Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension’, Pain, vol. 159, no. 12, pp. 2573-2584
• Grundy L, Daly DM, Chapple C, Grundy D, Chess-Williams Russ. 2018, ‘TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder’, Scientific reports, vol. 8, no. 1, pp. 197
• Grundy L, Caldwell A, Garcia-Caraballo S, Grundy D, Spencer NJ, Dong X et al. 2021, ‘Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension’, The Journal of Neuroscience, vol. 41, no. 17, pp. 3900–3916